Aspirin Resistance in Hypertensive Patients.
Although there is no standardized definition of aspirin resistance it is generally accepted to mean a lack of exhibiting beneficial effects to therapeutic doses of aspirin.
Aspirin resistance is associated with poor clinical prognosis. The authors investigated aspirin resistance in 200 hypertensive patients by the Ultegra Rapid Platelet Function Assay-ASA. In this study Aspirin resistance was defined as an aspirin reaction unit >=550.
Aspirin resistance was detected in 42 patients. Aspirin resistance was present in 25.6% of the patients with poor blood pressure control, while in 17.8% of the patients with controlled blood pressure. Female gender and creatinine levels were significantly higher, while platelet count was significantly lower in aspirin-resistant patients. Multivariate analysis revealed that female gender, creatinine levels and platelet count were independent predictors of aspirin resistance.
The frequency of aspirin resistance is not low in hypertensive patients. Female hypertensive patients, especially, with higher creatinine levels and lower platelet count are at higher risk for aspirin resistance.
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